TESTOLON – Testosterone Propionate 120mg/ml 5x2ml Box
PHARMACEUTICAL NAME: Testosterone Propionate
MOLECULAR STRUCTURE: C22H32O3
PROPRIETARY NAME: TESTOLON
DOSAGE FORM: 120 mg/ml injection
COMPOSITION: Each ml of TESTOLON contains Testosterone Propionate 120 mg in oily base quantity sufficient.
PHARMACOLOGICAL CLASSIFICATION: Androgenic Hormone
DESCRIPTION:
Testosterone is secreted from Leydig cell of testes. It is responsible for development of secondary sex characters in males at the time of puberty and subsequent maintenance of spermatogenesis during reproductive life of males. It binds to intracellular receptors in target cells where as the hormone receptor complex translocates to nucleus where it attaches to specific binding sites on the chromosomes. This leads to increased synthesis of mRNAand protein.
PHARMACOKINETIC PROPERTIES:
Testosterone propionate is an oil-based injectable testosterone. Testosterone Propionate has anabolic as well as androgenic properties, as well as a shorter half life compared to cypionate & enanthate esters. Testosterone propionate has a duration of effect of 1 to 2 days, therefore, testosterone propionate is much faster acting than other testosterone esters.
Propionate is a rapidly effective testosterone that must be injected more often, and requires a much more frequent dosing schedule in order to maintain stable blood levels. Testosterone is 98% bound to a specific testosteroneestradiol binding globulin in plasma, and about 2% is free.
Approximately 90% of a dose of testosterone is excreated in the urine as glucuronic and sulphuric acid ie., conjugates of testosterone and its metabolites; 6% of a dose is excreated in the feaces, mostly in the conjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids.
INDICATIONS:
MALE: Testicular failure: hypogonadal disorders, eunuchiodism, endocrine impotence, hypopituitarism, loss of libido, delayed puberty, osteoporosis, infertility due to disorders of spermatogenesis, male climacteric symptoms, hereditary angioneurotic oedema.
FEMALE: Genitial carcinoma, endometriosis, fibroids, breast carcinoma, menopausal syndrome.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Testosterone Propionate, when administered in the body, is partially converted to both estrogen as well as Dihydrotestosterone. These are often the cause of many side effects such as gynaecomastia, water retention, hair loss and prostate enlargement. Also, as with most steroids, injected testosterone propionate will inhibit natural testosterone levels and HPTA(Hypothalamic Pituitary Testicular Axis). The advantage of testosterone propionate, in this respect, is that it will clear the system more quickly than other esters, and allow recovery to begin at a earlier stage. If there is a predisposition and very high dosages are taken, the known androgenic-linked side effects are acne vulgaris, accelerated hair loss, and increased growth of body hair and deep voice can occur
The toxic influence on the liver is minimal so that a liver damage is unlikely compared to enanthate esters. An increased libido is common both in men and women with the use of propionate. Testosterone Pharmed C O R P O R A T I O N propionate is a more painful injection, pronounced soreness and lowgrade fever that may last for a few days, with swelling and noticeable pain around the injection site.
CONTRAINDICATIONS:
Carcinoma of the male breast.
Carcinoma known or suspected of the prostate.
Cardiac, hepatic or renal impairment.
Hypercalcemia.
Prepubertal males.
Hypersensitivity to testosterone or any other excipients.
Pregnancy and feeding mothers as testosterone esters causes foetalharm.
DRUG INTERACTIONS
Anticoagulant: Testosterone may potentiate the effects of anticoagulant. Antidiabetic agents & Insulin: may reduce the blood glucose level & insulin in diabetic patients.
Oxyphenbutazone: concurrent administration of Oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
Rifampicin and Phenobarbitone may increase rate of metabolism.
PACKAGING:
BOX: 5 vials of 2 ml (120 mg/ml)
DOSAGE AND DIRECTIONS FOR USE:
TESTOLON injections should be administered intramuscularly. The most common dosage is 60 to 120 mg, every day or 2nd day and total weekly dosage would be in the range of 300-400 mg.
FEMALE: 60-120 mg three times in a week for the treatment of breast cancer in women.
STORAGE:
Not to be refrigerated. Protect from light. Store in cool place below 25 °C. Keep the ampoules in the outer carton, protect from light. TESTOLON should be kept out of reach of children.
MARKETED BY:
Pharmed Corporation Ltd., 3361/A, Rani Bagh, Mahindra Park Rajdhani Enclave, Shakurpur, New Delhi, Delhi 110034, India. tel +919953242466, http://www.pharmed-corp.com
DATE OF PUBLICATION OF THIS PACKAGE INSERT:
04.2020
